Description

(R,R)-2,7-Di-tert-Butyl-9,9-Dimethyl-4,5-Bis(Methylphenylphosphino)Xanthene is a high-value, chiral phosphine ligand essential for creating highly selective asymmetric catalytic systems. Its primary value lies in enabling the synthesis of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs) with superior efficiency and yield. This compound is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing advanced synthetic routes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical synthesis.
• Asymmetric C-C Bond Formation: Catalyzes critical reactions like cross-coupling and allylic alkylation to construct chiral carbon frameworks.
• Process Chemistry & API Development: Used in the scale-up and optimization of manufacturing processes for chiral drugs.
• Agrochemical Synthesis: Enables the production of enantiopure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial Research: A vital tool for developing novel catalytic methodologies and exploring new chemical space.
• Fine Chemical Production: Applied in the manufacture of specialty flavors, fragrances, and advanced materials requiring high optical purity.

Basic Information

Product Name	(R,R)-2,7-Di-tert-Butyl-9,9-Dimethyl-4,5-Bis(Methylphenylphosphino)Xanthene
CAS No.	221462-97-1
Molecular Formula	C43H56O1P2
Molecular Weight	650.86 g/mol
Synonyms	(R,R)-DTBM-SEGPHOS; (R,R)-2,7-Di-tert-butyl-9,9-dimethyl-4,5-bis(diphenylphosphino)-9H-xanthene (common naming variant); (R,R)-5,5'-Bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole (core SEGPHOS structure); (R,R)-DTBM-SEGPHOS Ligand; (11bR)-4,6-Bis[3,5-di-tert-butyl-4-methoxyphenyl]-2,10-dimethyldibenzo[d,f][1,3,2]dioxaphosphepin 6-oxide (related IUPAC); Chiral Phosphine Ligand; SEGPHOS Derivative; DTBM Modified SEGPHOS
EINECS	Contact for details

Quality Control

Every batch of our (R,R)-DTBM-SEGPHOS is manufactured under strict quality protocols to ensure exceptional purity and chiral integrity, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. Our quality system is designed to support cGMP and ISO standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use and stored in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.