Description

L-n-[(4'-Boc)Piperidino]Proline is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine-proline hybrid structure. This compound is critically important for the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel therapeutic agents, including protease inhibitors and other peptidomimetics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting enzymatic pathways.
• Peptidomimetic Research: Used to construct constrained peptide analogs and macrocyclic compounds for enhanced metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core scaffold in the design and optimization of inhibitors for various protease enzymes.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new chemical space and improve pharmacological profiles.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.
• Bioconjugation: The protected amine and carboxylic acid functionalities allow for selective deprotection and conjugation in biopharmaceutical applications.

Basic Information

Product Name	L-n-[(4'-Boc)Piperidino]Proline
CAS No.	221352-39-2
Molecular Formula	C16H28N2O4
Molecular Weight	312.41 g/mol
Synonyms	(2S)-1-[(4-tert-Butoxycarbonyl)piperidin-1-yl]pyrrolidine-2-carboxylic acid; 1-[(4-{[(1,1-Dimethylethoxy)carbonyl]amino}piperidin-1-yl)carbonyl]-L-proline; L-Proline, 1-[(4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl)carbonyl]-; Boc-4-Amino-piperidine-Proline; Boc-Pip-Pro-OH; N-[(4'-Boc)Piperidino]Proline; tert-Butyl 4-((S)-2-carboxypyrrolidine-1-carbonyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our L-n-[(4'-Boc)Piperidino]Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.