Description

Propanamide, 2-Methyl-n-[(3S)-Tetrahydro-2-Oxo-3-Furanyl]- is a high-purity chiral intermediate featuring a unique lactam-fused structure. This compound is of significant value in the synthesis of complex pharmaceutical molecules, particularly those targeting neurological and metabolic pathways. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing new active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel therapeutic agents, including protease inhibitors and enzyme modulators.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex heterocyclic frameworks and exploring new synthetic methodologies.
• Agrochemical Development: Serves as a precursor in the research and development of advanced, targeted crop protection agents.
• Asymmetric Catalysis Studies: Employed as a substrate or ligand precursor in the development of new chiral catalysts.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	Propanamide, 2-Methyl-n-[(3S)-Tetrahydro-2-Oxo-3-Furanyl]-
CAS No.	221292-05-3
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	(3S)-N-(2-Methylpropanoyl)-2-oxotetrahydrofuran-3-amine; (3S)-3-[(2-Methylpropanoyl)amino]dihydrofuran-2(3H)-one; 2-Methyl-N-[(3S)-2-oxooxolan-3-yl]propanamide; (S)-3-(Isobutyrylamino)dihydrofuran-2-one; Lactam Isobutyramide Derivative; Chiral Lactam Amide; 221292-05-3; API Intermediate 221292-05-3
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this chiral intermediate, ensuring it meets the exacting standards required for pharmaceutical R&D and production. Every batch is characterized using advanced analytical techniques including HPLC, GC, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.