Description

Tizoxanide Glucuronide, Sodium Salt is a key metabolite and pharmaceutical intermediate of the antiprotozoal agent tizoxanide. This compound is of significant interest for research and development in the pharmaceutical industry, particularly for studying drug metabolism, pharmacokinetics, and for use as a reference standard. It is primarily required by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers developing or producing antiparasitic medications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing of tizoxanide-based drug products.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the metabolic pathways, bioavailability, and excretion profiles of tizoxanide.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a high-purity synthetic intermediate in the production of advanced pharmaceutical formulations.
• Bioanalytical Assays: Employed in the calibration of LC-MS/MS and HPLC systems for the quantitative analysis of tizoxanide and its metabolites in biological matrices.
• Preclinical and Clinical Studies: Essential for pharmacokinetic (PK) and pharmacodynamic (PD) studies during drug development stages.

Basic Information

Product Name	Tizoxanide Glucuronide, Sodium Salt
CAS No.	221287-83-8
Molecular Formula	C19H15N2O10SNa
Molecular Weight	486.39 g/mol
Synonyms	2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide glucuronide sodium salt; Tizoxanide β-D-Glucuronide Sodium Salt; Nitazoxanide Metabolite Glucuronide Sodium Salt; 2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl β-D-glucopyranosiduronic acid sodium salt; TIZ-Gluc Sodium; 5-Nitro-2-[(2-benzoyl-4-hydroxyphenoxy)methyl]thiazole Glucuronide Sodium Salt (alternative representation); Sodium (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-((5-nitrothiazol-2-yl)carbamoyl)phenoxy)tetrahydro-2H-pyran-2-carboxylate
EINECS	Contact for details

Quality Control

Our Tizoxanide Glucuronide, Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets stringent standards for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay (on anhydrous basis)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.