Description

1-Bromo-2,4-difluoro-3-methoxybenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with precise electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the difluoro-methoxy-bromo motif contributes to enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic cores in electronic materials, improving charge transport, thermal stability, and emission properties in display technologies.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the rapid diversification of chemical space in medicinal chemistry libraries.
• Functional Dye & Pigment Intermediate: Employed in the synthesis of specialized fluorinated dyes and pigments that offer superior lightfastness and unique chromatic properties.
• Polymer Modification: Used to introduce fluorine and bromine functional groups into polymer backbones, altering surface energy, refractive index, and chemical resistance for high-performance polymers.

Basic Information

Product Name	1-Bromo-2,4-difluoro-3-methoxybenzene
CAS No.	221221-00-7
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	2,4-Difluoro-3-methoxybromobenzene; 3-Bromo-2,6-difluoroanisole; 2-Bromo-1,3-difluoro-4-methoxybenzene; Benzene, 1-bromo-2,4-difluoro-3-methoxy-; 3-Methoxy-2,4-difluorobromobenzene; 1-Bromo-2,4-difluoro-3-methoxy-benzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,4-difluoro-3-methoxybenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.