Description

(3-Fluoro-Phenyl)-Propynoic Acid Methyl Ester is a versatile fluorinated aromatic building block and a key intermediate in advanced organic synthesis. This compound is valued for its ability to introduce both a fluorinated phenyl group and a reactive propynoate moiety into target molecules, enabling the construction of complex chemical architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry and functional material design.

Application

• Pharmaceutical Intermediate: Serves as a crucial synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Research: Employed in academic and industrial laboratories for methodology development, including Sonogashira coupling, click chemistry, and other alkyne-based transformations.
• Fluorine Chemistry: A valuable reagent for introducing fluorine-containing aromatic systems into molecules to modulate their physicochemical properties, such as lipophilicity and metabolic profile.

Basic Information

Product Name	(3-Fluoro-Phenyl)-Propynoic Acid Methyl Ester
CAS No.	221148-38-5
Molecular Formula	C10H7FO2
Molecular Weight	178.16 g/mol
Synonyms	Methyl 3-(3-fluorophenyl)propiolate; Methyl (3-fluorophenyl)propynoate; 3-Fluorophenylpropiolic acid methyl ester; 3-(3-Fluorophenyl)-2-propynoic acid methyl ester; (3-Fluorophenyl)propiolic acid methyl ester; Propargylic acid, 3-(3-fluorophenyl)-, methyl ester; m-Fluorophenylpropiolic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of (3-Fluoro-Phenyl)-Propynoic Acid Methyl Ester is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.