Description

4-(4-Fluoro-Phenyl)-3-Oxo-Butyric Acid Ethyl Ester is a high-purity, versatile β-keto ester building block, essential for advanced organic synthesis. Its core value lies in providing a reactive scaffold for constructing complex molecules, particularly in the synthesis of heterocyclic compounds and active pharmaceutical ingredients (APIs). This compound is critically needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various heterocyclic compounds, including pyrazoles, isoxazoles, and pyrimidines, which are core structures in many APIs.
• Agrochemical Synthesis: Used as a building block for developing novel herbicides, fungicides, and insecticides, leveraging the fluorophenyl moiety for enhanced biological activity.
• Fine Chemical Production: Serves as a versatile starting material for synthesizing complex flavors, fragrances, and functional materials.
• Academic & Industrial R&D: Employed in research laboratories for method development and exploring new chemical entities in medicinal chemistry programs.
• Chemical Library Construction: Utilized in combinatorial chemistry for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	4-(4-Fluoro-Phenyl)-3-Oxo-Butyric Acid Ethyl Ester
CAS No.	221121-37-5
Molecular Formula	C12H13FO3
Molecular Weight	224.23 g/mol
Synonyms	Ethyl 4-(4-fluorophenyl)-3-oxobutanoate; Ethyl 4-(p-fluorophenyl)-3-oxobutyrate; 3-Oxo-4-(4-fluorophenyl)butyric acid ethyl ester; 4-(4-Fluorophenyl)-3-oxobutanoic acid ethyl ester; 4-(p-Fluorophenyl)acetoacetic acid ethyl ester; p-Fluorophenylacetoacetic acid ethyl ester; 221121-37-5
EINECS	Contact for details

Quality Control

Our 4-(4-Fluoro-Phenyl)-3-Oxo-Butyric Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring GMP-grade intermediates and reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.