Description

4-(2-Fluoro-Phenyl)-3-Oxo-Butyric Acid Ethyl Ester is a high-purity fluorinated β-keto ester building block, essential for advanced organic synthesis. Its molecular structure, featuring a reactive β-keto ester moiety adjacent to a fluorinated aromatic ring, makes it a versatile precursor for constructing complex heterocycles and active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with enhanced biological activity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used as a precursor for developing novel fluorinated pesticides and herbicides, where the fluorine atom can improve metabolic stability and bioavailability.
• Chemical Research & Development: Serves as a critical reagent in academic and industrial R&D for exploring new reactions in fluoroorganic chemistry and synthesizing complex molecular libraries.
• Material Science Precursor: Employed in the development of advanced organic materials, including liquid crystals and functional polymers, where fluorinated aromatic units are required.
• Heterocyclic Compound Synthesis: A fundamental starting material for the construction of various fluorinated heterocycles such as pyrazoles, isoxazoles, and pyrimidines via condensation and cyclization reactions.

Basic Information

Product Name	4-(2-Fluoro-Phenyl)-3-Oxo-Butyric Acid Ethyl Ester
CAS No.	221121-35-3
Molecular Formula	C₁₂H₁₃FO₃
Molecular Weight	224.23 g/mol
Synonyms	Ethyl 4-(2-Fluorophenyl)-3-oxobutanoate; Ethyl 2-Fluorobenzoylacetate; 3-Oxo-4-(2-fluorophenyl)butyric Acid Ethyl Ester; 2-Fluorophenyl 3-Oxobutanoate Ethyl Ester; 4-(2-Fluorophenyl)acetoacetic Acid Ethyl Ester; 2-Fluorobenzoylacetic Acid Ethyl Ester; Ethyl (2-Fluorobenzoyl)acetate; Butyric acid, 4-(2-fluorophenyl)-3-oxo-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of 4-(2-Fluoro-Phenyl)-3-Oxo-Butyric Acid Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR, IR) to verify identity, potency, and impurity profiles. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.