Description

3,5-Difluoro-4-(Trifluoromethoxy)Phenylboronic Acid is a high-value, multi-fluorinated boronic acid derivative, a crucial building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules via the robust Suzuki-Miyaura cross-coupling reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce a highly functionalized, fluorinated aromatic moiety into target molecules, thereby fine-tuning their biological activity, metabolic stability, and physical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethoxy groups enhance lipophilicity and biological efficacy.
• Material Science Research: Serves as a precursor for synthesizing novel organic electronic materials, such as fluorinated polymers and small molecules for OLEDs or semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create fluorinated probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	3,5-Difluoro-4-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	220943-57-7
Molecular Formula	C7H4BF5O3
Molecular Weight	241.91 g/mol
Synonyms	[4-(Trifluoromethoxy)-3,5-difluorophenyl]boronic acid; 3,5-Difluoro-4-(trifluoromethoxy)benzeneboronic acid; (3,5-Difluoro-4-(trifluoromethoxy)phenyl)boronic acid; Boronic acid, B-[3,5-difluoro-4-(trifluoromethoxy)phenyl]-; 220943-57-7; 4-Trifluoromethoxy-3,5-difluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-(Trifluoromethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.