Description

Buspirone n-Oxide CAS NO 220747-81-9 is a significant pharmaceutical intermediate and metabolite of the anxiolytic drug buspirone. This compound is of high importance for research and development in neuropharmacology and analytical chemistry. It serves as a critical reference standard for pharmacokinetic studies, impurity profiling, and method validation. Key industries that require this material include pharmaceutical R&D, contract research organizations (CROs), and analytical testing laboratories.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of buspirone and its metabolites in biological matrices.
• Metabolite Research: Essential for studying the metabolic pathways, pharmacokinetics, and pharmacodynamics of buspirone in preclinical and clinical research.
• Impurity Profiling: Acts as a known impurity standard in the quality control of buspirone active pharmaceutical ingredient (API) to ensure product purity and safety.
• Analytical Method Development: Utilized in the development and validation of HPLC, LC-MS, and other chromatographic methods for accurate assay determination.
• Pharmacology Studies: Employed in investigative studies to understand the activity and role of buspirone metabolites in the body.
• Regulatory Submissions: Supports regulatory filings (e.g., for FDA, EMA) by providing necessary data on drug metabolites and impurities.

Basic Information

Product Name	Buspirone n-Oxide
CAS No.	220747-81-9
Molecular Formula	C21H31N5O3
Molecular Weight	401.50 g/mol
Synonyms	8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione 1-oxide; Buspirone N-Oxide; Buspirone Metabolite 6; BMY 13805-1; UNII-8JQ5607IO5
EINECS	Contact for details

Quality Control

Our Buspirone n-Oxide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with relevant standards for research and reference materials. Our quality commitment supports your regulatory and research integrity needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.