Description

Propanenitrile, 2-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-, (2S)- (9Ci) is a chiral, protected cyanohydrin derivative that serves as a versatile synthetic intermediate in advanced organic synthesis. Its value lies in its ability to introduce a nitrile functional group with defined stereochemistry, enabling the construction of complex, optically active molecules. This high-purity building block is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of chiral pesticides, herbicides, and other crop protection agents.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to construct stereogenic centers.
• Fine Chemical Production: Serves as a precursor for the manufacture of specialty chemicals, flavors, and fragrances requiring specific chirality.
• Academic & Industrial R&D: A valuable tool for methodological development and discovery chemistry in laboratory settings.
• Peptidomimetics & Bioactive Molecule Construction: Used to incorporate nitrile-containing amino acid analogs and other bioactive scaffolds.

Basic Information

Product Name	Propanenitrile, 2-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-, (2S)- (9Ci)
CAS No.	220666-10-4
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	(2S)-2-[(Tetrahydro-2H-pyran-2-yl)oxy]propanenitrile; (S)-2-((Tetrahydro-2H-pyran-2-yl)oxy)propanenitrile; (S)-2-(Tetrahydro-2H-pyran-2-yloxy)propionitrile; (S)-2-(Tetrahydropyran-2-yloxy)propionitrile; THP-protected (S)-Lactonitrile; (S)-Lactonitrile THP ether; 2-[(Tetrahydro-2H-pyran-2-yl)oxy]propanenitrile, (2S)-
EINECS	Contact for details

Quality Control

Our Propanenitrile, 2-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-, (2S)- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to meet the exacting standards required for synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.