Description

3,5-Difluorophenacyl Bromide is a high-purity, versatile fluorinated organic bromide building block essential for advanced chemical synthesis. This compound is critical for introducing the difluorophenacyl moiety into target molecules, enabling the development of novel materials and active compounds with tailored properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications ranging from medicinal chemistry to material science.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic ketone functionalities.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides where the difluorophenyl group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials to modify solubility and electronic properties.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags, photoaffinity labels, and other molecular probes for biochemical and cellular studies.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3,5-Difluorophenacyl Bromide
CAS No.	220607-75-0
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	2-Bromo-1-(3,5-difluorophenyl)ethan-1-one; 3,5-Difluorophenacyl bromide; 1-(3,5-Difluorophenyl)-2-bromoethanone; α-Bromo-3,5-difluoroacetophenone; 2-Bromo-3',5'-difluoroacetophenone; (3,5-Difluorophenyl)-2-bromoethanone; Bromo(3,5-difluorophenyl)methanone
EINECS	Contact for details

Quality Control

Every batch of 3,5-Difluorophenacyl Bromide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical synthetic applications. A Certificate of Analysis (COA) detailing specifications such as assay (by HPLC/NMR), identity (by IR/GC-MS), and impurity profile is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.