Description

Fmoc-D-Propargylglycine CAS NO 220497-98-3 is a non-natural, chiral amino acid derivative featuring a propargyl side chain protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the site-specific introduction of alkyne functional groups for subsequent bioorthogonal click chemistry reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is essential for researchers and manufacturers in pharmaceutical development, chemical biology, and proteomics who require precise peptide modification, labeling, or conjugation to create novel drug candidates, diagnostic probes, and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a protected amino acid building block for the automated synthesis of peptides containing alkyne handles.
• Bioconjugation & Protein Labeling: Enables site-specific modification of peptides and proteins via click chemistry with azide-containing dyes, polymers, or other molecules.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates to create conjugates for targeted drug delivery or to enhance pharmacokinetic properties.
• Chemical Biology Probes: Synthesis of activity-based probes (ABPs) or photoaffinity labels for studying enzyme function and protein-protein interactions.
• Material Science: Used to create functionalized peptides for the development of smart biomaterials and hydrogels.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the construction of linker-payload systems for next-generation ADCs.
• Peptide Library Synthesis: Key component in generating diverse peptide libraries for high-throughput screening in drug discovery.
• Diagnostic Assay Development: Used to prepare peptide antigens or tracers for immunoassays and diagnostic kits.

Basic Information

Product Name	Fmoc-D-Propargylglycine
CAS No.	220497-98-3
Molecular Formula	C₂₁H₁₉NO₄
Molecular Weight	349.38 g/mol
Synonyms	Fmoc-D-2-amino-5-hexynoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-2-amino-5-hexynoic acid; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hex-5-ynoic acid; Fmoc-D-Pra-OH; Fmoc-D-propargylgly-OH; D-Fmoc-propargylglycine; N-Fmoc-D-propargylglycine; Fmoc-D-2-amino-hex-5-ynoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-Propargylglycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for advanced peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral HPLC analysis, and identity confirmation are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); desiccate upon opening and keep under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (D-isomer)
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.