Description

Fmoc-5-Bromo-2-Methoxy-D-Phenylalanine is a non-natural, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the research and development of novel peptide-based pharmaceuticals and bioactive molecules. It is primarily utilized by medicinal chemists and research scientists in pharmaceutical R&D, biotechnology, and academic institutions for creating complex peptides with enhanced stability, specificity, and therapeutic potential.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the sequential assembly of custom peptides.
• Pharmaceutical Research: Incorporation into peptide drug candidates to modulate bioactivity, improve metabolic stability, or introduce specific molecular interactions.
• Peptidomimetic Design: Serves as a precursor for creating peptidomimetics and constrained peptides, where the bromo and methoxy substituents allow for further chemical modifications.
• Chemical Biology Probes: Used in the synthesis of labeled or tagged peptides for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Antibody-Drug Conjugate (ADC) Linker/Payload Construction: Can be integrated into the peptide-based components of ADC linker systems.
• Material Science: Potential use in the synthesis of peptide-based polymers or biomaterials with specific functional properties.

Basic Information

Product Name	Fmoc-5-Bromo-2-Methoxy-D-Phenylalanine
CAS No.	220497-84-7
Molecular Formula	C₂₅H₂₂BrNO₅
Molecular Weight	496.35 g/mol
Synonyms	Fmoc-5-Br-2-OMe-D-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-bromo-2-methoxy-D-phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-bromo-2-methoxyphenyl)propanoic acid; Fmoc-D-5-Bromo-2-methoxyphenylalanine; Fmoc-5-Bromo-O-methyl-D-tyrosine; Fmoc-D-Br(5)OMe(2)Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-5-Bromo-2-Methoxy-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the high standards required for advanced peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.