Description

Fmoc-(S)-3-Amino-3-(4-Bromo-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a brominated aromatic side chain. This compound is a critical chiral building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of unique structural motifs. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing novel therapeutic peptides and constrained analogs.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides with bromo-phenyl functionalization.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Used to incorporate rigid, aromatic side chains into peptidomimetic scaffolds to modulate biological activity and stability.
• Chemical Biology Probes: Enables the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Combinatorial Chemistry Libraries: A valuable building block for creating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-(S)-3-Amino-3-(4-Bromo-Phenyl)-Propionic Acid
CAS No.	220497-68-7
Molecular Formula	C24H20BrNO4
Molecular Weight	466.33 g/mol
Synonyms	Fmoc-3-Amino-3-(4-bromophenyl)propanoic acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-bromophenyl)propanoic acid; Fmoc-(S)-Amino(4-bromophenyl)acetic acid, β-homo; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(4-bromophenyl)-β-alanine; Fmoc-4-Br-Phe(3-COOH); Fmoc-β-homo-4-bromo-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-3-(4-Bromo-Phenyl)-Propionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a comprehensive Certificate of Analysis (COA). We adhere to cGMP principles for production, ensuring traceability and reliability for pharmaceutical-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.