Description

Cys(Npys)-Antennapedia Homeobox (43-58) Amide is a chemically modified, cell-penetrating peptide (CPP) derivative of the Antennapedia homeodomain sequence. This compound is specifically engineered for advanced research in cellular delivery and protein-protein interaction studies, offering a reactive pyridyl disulfide group for site-specific conjugation. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of drug discovery, neurobiology, and intracellular signaling pathway analysis. The product is supplied as a high-purity synthetic peptide to ensure reliable and reproducible experimental results.

Application

• Intracellular Delivery Research: As a model cell-penetrating peptide (CPP) for studying mechanisms of membrane translocation and cargo delivery into cells.
• Bioconjugation & Probe Development: The reactive Cys(Npys) moiety allows for efficient, site-specific coupling to thiol-containing molecules, fluorescent dyes, or other payloads to create targeted research tools.
• Signal Transduction Studies: Used to investigate the role of homeodomain proteins in gene regulation, development, and cellular differentiation by modulating intracellular targets.
• Neuroscience Research: Applied in studies exploring neuronal development, axon guidance, and the function of homeobox genes in the nervous system.
• Drug Discovery Platforms: Serves as a component in screening assays and platforms designed to identify inhibitors or modulators of protein-protein interactions involving homeodomains.
• Peptide Therapeutics Development: Acts as a precursor or model compound for designing novel therapeutic peptides with enhanced cellular uptake properties.

Basic Information

Product Name	Cys(Npys)-Antennapedia Homeobox (43-58) Amide
CAS No.	220337-24-6
Molecular Formula	C91H138N30O21S3
Molecular Weight	2116.5 g/mol
Synonyms	Antp(43-58)-Cys(Npys) amide; Penetratin (43-58) derivative; Cys(3-nitro-2-pyridinesulfenyl)-Antennapedia homeodomain (43-58) amide; pAntp(43-58)-Cys(Npys); Cell-penetrating peptide Antp analog; Cys(Npys)-RQIKIWFQNRRMKWKK-NH2; 3-Nitro-2-pyridinesulfenyl-cysteinyl-Antennapedia homeobox peptide; CPP-Antp conjugate precursor
EINECS	Contact for details

Quality Control

Our synthetic peptides are manufactured under strict cGMP-like conditions to ensure the highest standards of purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and Mass Spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, molecular weight, and analytical data are provided with every shipment and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Molecular Weight	2116.5 ± 2.0 Da
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.