Description

2(3H)-Furanone,3,3-Difluorodihydro-4,4-Dimethyl-(9Ci) is a specialized fluorinated lactone building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular structure, which incorporates both a reactive lactone moiety and geminal difluoromethylene groups, enabling the precise introduction of fluorine atoms to modulate the properties of target molecules. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides, where fluorine atoms can improve biological activity and environmental persistence profiles.
• Material Science Precursor: Serves as a building block for specialty polymers and advanced materials requiring specific fluorine content for altered surface properties or chemical resistance.
• Fluorine Chemistry Research: An important reagent in academic and industrial R&D for studying new fluorination methodologies and constructing complex fluorinated heterocycles.
• Ligand and Catalyst Development: Utilized in the synthesis of fluorinated ligands for catalysis, potentially enhancing selectivity and efficiency in asymmetric synthesis.

Basic Information

Product Name	2(3H)-Furanone,3,3-Difluorodihydro-4,4-Dimethyl-(9Ci)
CAS No.	220294-25-7
Molecular Formula	C6H8F2O2
Molecular Weight	150.12 g/mol
Synonyms	3,3-Difluoro-4,4-dimethyldihydrofuran-2(3H)-one; 4,4-Dimethyl-3,3-difluorodihydro-2(3H)-furanone; 3,3-Difluoro-4,4-dimethylbutyrolactone; Dihydro-3,3-difluoro-4,4-dimethyl-2(3H)-furanone; 3,3-Difluoro-4,4-dimethyl-γ-butyrolactone; 9CI Index Name: 2(3H)-Furanone, 3,3-difluorodihydro-4,4-dimethyl- Fluorinated Lactone Building Block 220294-25-7
EINECS	Contact for details

Quality Control

Our 2(3H)-Furanone,3,3-Difluorodihydro-4,4-Dimethyl-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and batch-to-batch consistency critical for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong alkalis and sources of fluoride ions. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.