Description

2,4,6-Trifluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique trifluoromethyl-substituted phenyl ring structure makes it a critical intermediate for constructing complex molecules with enhanced properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays.
• Functional Material Development: Intermediate for creating specialty polymers, dyes, and electronic chemicals with specific optical or electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination to create complex biaryl structures.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and heterocyclic chemistry.

Basic Information

Product Name	2,4,6-Trifluorophenylacetonitrile
CAS No.	220227-80-5
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	2-(2,4,6-Trifluorophenyl)acetonitrile; (2,4,6-Trifluorophenyl)acetonitrile; α-Cyano-2,4,6-trifluorotoluene; 2,4,6-Trifluorobenzyl cyanide; 2,4,6-Trifluorophenyl cyanomethyl; 220227-80-5; Acetonitrile, (2,4,6-trifluorophenyl)-
EINECS	Contact for details

Quality Control

Our 2,4,6-Trifluorophenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.