Description

4-Fluoro-3-(trifluoromethyl)phenylacetic acid is a high-value fluorinated aromatic building block characterized by its phenylacetic acid core substituted with fluorine and a trifluoromethyl group. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where its unique fluorinated structure imparts desirable metabolic stability and bioavailability. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and amide bond formations to introduce the fluorinated phenylacetic acid moiety into more complex molecules.
• Material Science Research: Investigated for use in the development of specialty polymers and advanced materials with specific surface properties.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethyl)phenylacetic Acid
CAS No.	220227-47-4
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	2-(4-Fluoro-3-(trifluoromethyl)phenyl)acetic Acid; [4-Fluoro-3-(trifluoromethyl)phenyl]acetic Acid; 4-Fluoro-α,α,α-trifluoro-m-toluic Acid (related); 2-(4-Fluoro-3-trifluoromethylphenyl)acetic Acid; 4-Fluoro-3-trifluoromethylbenzeneacetic Acid; α-Carboxy-4-fluoro-3-trifluoromethyltoluene; F3C-Ph(F)-CH2COOH (abbrev.)
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(trifluoromethyl)phenylacetic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under dry conditions to prevent product degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.