Description

2,4,5-Trifluorobenzenesulfonyl Chloride is a high-value, multi-fluorinated aromatic sulfonyl chloride derivative. This compound serves as a critical sulfonating agent and versatile synthetic building block in advanced organic synthesis, enabling the introduction of the sulfonyl group into complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs), including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and pesticides with enhanced efficacy and selectivity.
• Material Science: Used in the production of specialty polymers, dyes, and liquid crystal materials where fluorinated sulfonyl groups impart specific chemical and physical properties.
• Chemical Research: Essential reagent in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies and route scouting.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions to form carbon-sulfur bonds.

Basic Information

Product Name	2,4,5-Trifluorobenzenesulfonyl Chloride
CAS No.	220227-21-4
Molecular Formula	C6H2ClF3O2S
Molecular Weight	230.59 g/mol
Synonyms	2,4,5-Trifluorobenzene-1-sulfonyl chloride; 1,2,4-Trifluoro-5-chlorosulfonylbenzene; Benzenesulfonyl chloride, 2,4,5-trifluoro-; 2,4,5-Trifluorophenylsulfonyl chloride; 2,4,5-Trifluorobenzenesulphonyl chloride; 220227-21-4; 2,4,5-Trifluoro-benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluorobenzenesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and GC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.