Description

(+)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(3,5-Difluoromethylphenyl)Phosphino]Butane is a high-value, chiral bisphosphine ligand crucial for enabling highly selective catalytic transformations. Its primary value lies in its ability to induce exceptional enantioselectivity in asymmetric hydrogenation and other transition metal-catalyzed reactions, which is critical for producing single-enantiomer intermediates. This compound is essential for research and development chemists and process engineers in the pharmaceutical and fine chemical industries who require precise stereochemical control for synthesizing active pharmaceutical ingredients (APIs) and advanced agrochemicals.

Application

• Asymmetric Hydrogenation Catalyst Ligand: A key component for the enantioselective hydrogenation of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Synthesis: Used in the production of chiral drug candidates and complex molecules requiring high optical purity.
• Fine Chemical Manufacturing: Enables the synthesis of enantiomerically pure flavors, fragrances, and specialty agrochemicals.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in organic synthesis.
• Transition Metal Complex Formation: Serves as a chelating ligand for rhodium, ruthenium, and iridium to form highly active and selective catalysts.
• Process Chemistry Optimization: Employed to improve the yield, selectivity, and efficiency of large-scale chiral manufacturing processes.

Basic Information

Product Name	(+)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(3,5-Difluoromethylphenyl)Phosphino]Butane
CAS No.	220196-30-5
Molecular Formula	C38H32F8O2P2
Molecular Weight	742.60 g/mol
Synonyms	(+)-DIPAMP-Diol Ketal; (2R,3R)-(-)-1,4-Bis[bis(3,5-bis(trifluoromethyl)phenyl)phosphino]-2,3-O-isopropylidenebutane; (R,R)-DIPAMP Diol Ketal; (R,R)-1,2-O-Isopropylidene-4,5-bis[bis[3,5-bis(trifluoromethyl)phenyl]phosphino]pentane-1,2-diol; Asymmetric Hydrogenation Ligand; Chiral Diphosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced and tested under strict quality control protocols to ensure consistent high purity and performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and key impurity profiles. Our quality system is designed to meet the rigorous standards required for pharmaceutical R&D and cGMP applications, ensuring reliability for your critical synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.