Description

(R,R)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(3,5-Dimethylphenyl)Phosphino]Butane is a high-value, chiral bisphosphine ligand essential for creating highly selective asymmetric catalytic systems. Its primary value lies in enabling the synthesis of enantiomerically pure intermediates for pharmaceuticals and fine chemicals with exceptional enantioselectivity and yield. This product is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for advanced asymmetric hydrogenation and related transition metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation Catalyst Ligand: Key component for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Production: Enables the manufacture of chiral active pharmaceutical ingredients (APIs) for cardiovascular, central nervous system, and antiviral drugs.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Manufacturing: Facilitates the creation of high-value chiral flavor and fragrance compounds.
• Academic and Industrial R&D: A vital tool for research in organometallic chemistry and the development of new catalytic methodologies.
• Process Chemistry Optimization: Employed to scale up and optimize commercial synthetic routes requiring high stereochemical control.

Basic Information

Item	Details
Product Name	(R,R)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(3,5-Dimethylphenyl)Phosphino]Butane
CAS No.	220196-29-2
Molecular Formula	C46H56O2P2
Molecular Weight	702.89 g/mol
Synonyms	(R,R)-DIPAMP; (R,R)-1,2-Bis[(o-methoxyphenyl)(phenyl)phosphino]ethane (common mis-association); (R,R)-(-)-1,2-Bis(o-anisylphenylphosphino)ethane; (2R,3R)-(-)-Bis(diphenylphosphino)butane (BDCP); (R,R)-Chiraphos derivative; (R,R)-DIOP analog; (R,R)-Bisphospholane ligand; (R,R)-TADDOL-based phosphine
EINECS	Contact for details

Quality Control

Every batch of our (R,R)-o-Isopropylidene-2,3-Dihydroxy-1,4-Bis[Bis(3,5-Dimethylphenyl)Phosphino]Butane undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, critical for reproducible catalytic performance. Our quality protocols are designed to meet the stringent requirements of cGMP and ISO 9001 standards for advanced chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.