Description

1,4-Bis[Bis(3,5-Ditrifluoromethylphenyl)Phosphino]Butane is a highly specialized, electron-deficient bisphosphine ligand designed for demanding catalytic transformations. Its core value lies in enabling high-performance cross-coupling and hydrogenation reactions, particularly for synthesizing complex pharmaceutical intermediates and advanced materials. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require robust and selective catalysts for challenging substrates.

Application

• Catalyst Ligand for Cross-Coupling Reactions: Highly effective in Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings, especially with sterically hindered or electron-poor substrates.
• Asymmetric Hydrogenation: Used in the synthesis of chiral pharmaceutical intermediates where high enantioselectivity is critical.
• Pharmaceutical Intermediate Synthesis: Key component in catalytic steps for producing active pharmaceutical ingredients (APIs) and complex organic molecules.
• Agrochemical Manufacturing: Facilitates the synthesis of advanced, high-performance crop protection agents.
• Material Science Research: Employed in the development of novel polymers, OLED materials, and other functional materials via metal-catalyzed polymerization or functionalization.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic pathways in both academic laboratories and industrial research settings.

Basic Information

Product Name	1,4-Bis[Bis(3,5-Ditrifluoromethylphenyl)Phosphino]Butane
CAS No.	220185-41-1
Molecular Formula	C36H20F24P2
Molecular Weight	922.47 g/mol
Synonyms	DTBM-Segphos; 1,4-Butanediylbis[bis[3,5-bis(trifluoromethyl)phenyl]phosphine]; Josiphos ligand derivative; Bisphosphine ligand DTBM; 1,4-Bis(di(3,5-di(trifluoromethyl)phenyl)phosphino)butane; Electron-deficient bisphosphine; (R)-(–)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine analog
EINECS	Contact for details

Quality Control

Our 1,4-Bis[Bis(3,5-Ditrifluoromethylphenyl)Phosphino]Butane is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to verify identity, purity, and the absence of critical impurities like phosphine oxides. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxygen and moisture, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Phosphine Oxide Content (31P NMR)	≤ 2.0%
Solubility	Soluble in common organic solvents (THF, Toluene, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.