Description

Bis[Bis(3,5-Ditrifluoromethylphenyl)Phosphino]Methane is a specialized, high-value organophosphorus ligand with a unique bisphosphine structure. This compound is critical for enabling highly efficient and selective catalytic transformations in advanced chemical synthesis. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries for developing novel synthetic routes and optimizing existing processes.

Application

• Homogeneous Catalysis: As a sophisticated ligand in transition metal-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Heck, Sonogashira) for constructing complex molecular architectures.
• Pharmaceutical Intermediates: Facilitating the synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates, particularly those requiring chiral centers or fluorinated motifs.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where its electron-withdrawing trifluoromethyl groups can enhance biological activity and stability.
• Asymmetric Hydrogenation: Serving as a chiral or sterically demanding ligand for the enantioselective reduction of prochiral olefins, ketones, and imines.
• Material Science Research: A precursor for creating novel metal-organic frameworks (MOFs) or catalysts for polymerization and specialty polymer production.
• Academic & Industrial R&D: A valuable tool for methodological development in organic and organometallic chemistry laboratories worldwide.

Basic Information

Product Name	Bis[Bis(3,5-Ditrifluoromethylphenyl)Phosphino]Methane
CAS No.	220185-39-7
Molecular Formula	C31H12F24P2
Molecular Weight	878.36 g/mol
Synonyms	Bis[bis(3,5-bis(trifluoromethyl)phenyl)phosphino]methane; Methanediylbis[bis[3,5-bis(trifluoromethyl)phenyl]phosphine]; 1,1'-(Methanediyl)bis[1,1-bis[3,5-bis(trifluoromethyl)phenyl]phosphine]; DTFM-Methane; (3,5-(CF3)2C6H3)2PCH2P(C6H3(CF3)2-3,5)2; Ligand L* (context-dependent); Bisphosphine ligand with electron-withdrawing aryl groups
EINECS	Contact for details

Quality Control

Our Bis[Bis(3,5-Ditrifluoromethylphenyl)Phosphino]Methane is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, essential for reproducible catalytic performance. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, identity, and moisture content. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of advanced R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. This material is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.