Description

1,4-Bis[Bis(3,5-Dimethylphenyl)Phosphino]Butane CAS NO 220185-37-5 is a high-purity, sterically hindered bidentate phosphine ligand, essential for facilitating advanced catalytic transformations. Its primary value lies in enabling highly selective and efficient cross-coupling reactions, which are critical for constructing complex molecular architectures. This ligand is indispensable for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require robust and reliable catalysts for fine chemical synthesis.

Application

• As a key ligand in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig amination.
• Catalyst component for the synthesis of active pharmaceutical ingredients (APIs) and complex drug intermediates.
• Use in the development of novel agrochemicals and specialty fine chemicals requiring selective C-C and C-N bond formation.
• Research and development of new homogeneous catalysts for asymmetric synthesis and hydrogenation processes.
• Material science applications, including the synthesis of conjugated polymers and organic electronic materials.
• Process development and scale-up in contract manufacturing organizations (CMOs) for pharmaceutical production.

Basic Information

Product Name	1,4-Bis[Bis(3,5-Dimethylphenyl)Phosphino]Butane
CAS No.	220185-37-5
Molecular Formula	C36H44P2
Molecular Weight	538.68 g/mol
Synonyms	1,4-Bis[bis(3,5-dimethylphenyl)phosphino]butane; dtbpx; DTBpx Ligand; 1,4-Butanediylbis[bis(3,5-dimethylphenyl)phosphine]; Bis(3,5-dimethylphenyl)phosphino butane; DTBpx; DTBpx Phosphine Ligand; 1,4-Bis(di-3,5-xylylphosphino)butane
EINECS	Contact for details

Quality Control

Our production of 1,4-Bis[Bis(3,5-Dimethylphenyl)Phosphino]Butane adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including NMR, HPLC, and elemental analysis, to verify identity, purity, and the absence of critical impurities like phosphine oxides. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance in cGMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, containers must be kept sealed and purged with inert gas after each use to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Phosphine Oxide Content (³¹P NMR)	≤ 1.0%
Solubility	Soluble in common organic solvents (THF, Toluene, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.