Description

6-o-Desmethyl Donepezil β-D-Glucuronide is a key metabolite and reference standard of the acetylcholinesterase inhibitor donepezil. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic laboratories engaged in neuroscience and analytical chemistry.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and identification of donepezil metabolites in biological matrices during clinical and preclinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Critical for investigating the metabolic pathways, clearance mechanisms, and bioavailability of donepezil.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, and LC-MS/MS methods for therapeutic drug monitoring and pharmacokinetic assays.
• Impurity Profiling: Acts as a known impurity or degradation product standard to ensure the purity and stability of donepezil active pharmaceutical ingredient (API) formulations.
• Toxicology Studies: Employed in safety assessment studies to understand the profile and potential effects of donepezil metabolites.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring comprehensive characterization of drug metabolites.

Basic Information

Product Name	6-o-Desmethyl Donepezil β-D-Glucuronide
CAS No.	220170-73-0
Molecular Formula	C28H34N2O9
Molecular Weight	542.58 g/mol
Synonyms	6-O-Desmethyl Donepezil Glucuronide; Donepezil Metabolite 6-O-Desmethyl Glucuronide; 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine 6-O-Desmethyl-β-D-Glucuronide; ARICEPT Metabolite; (2R,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[4-[(5,6-dimethoxy-1-oxo-2,3-dihydroinden-2-yl)methyl]-1-benzylpiperidin-1-ium-1-yl]oxane-2-carboxylate
EINECS	Contact for details

Quality Control

Our 6-o-Desmethyl Donepezil β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical reference materials. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to protect from humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.