Description

Fmoc-L-β-Homotyrosine(Otbu) is a protected, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide structure and function, particularly when incorporating tyrosine analogs with extended side chains. It is an essential building block for pharmaceutical R&D, enabling the creation of novel peptide-based therapeutics, diagnostic agents, and biochemical tools. The product is supplied to the highest purity standards to ensure optimal coupling efficiency and final product integrity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of custom peptides.
• Pharmaceutical Research: Used in the discovery and development of novel peptide drugs, hormones, and enzyme inhibitors.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescently labeled or biotinylated peptides for diagnostic and imaging applications.
• Structure-Activity Relationship (SAR) Studies: Incorporation of the β-homotyronsine side chain allows researchers to study the effect of side chain length and flexibility on biological activity.
• GPCR Ligand Synthesis: Valuable for synthesizing peptide ligands targeting G-protein coupled receptors, where tyrosine analogs are common.
• Academic & Institutional Research: A fundamental reagent in biochemistry and molecular biology laboratories for protein engineering and chemical biology projects.

Basic Information

Product Name	Fmoc-L-β-Homotyrosine(Otbu)
CAS No.	219967-69-8
Molecular Formula	C29H31NO6
Molecular Weight	489.56 g/mol
Synonyms	Fmoc-β-HomoTyr(OtBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(4-[(1,1-dimethylethoxy)phenyl]-L-homoalanine; Fmoc-L-β-homotyronsine(OtBu); Fmoc-β-homo-tyr(OtBu); Nα-Fmoc-L-β-homotyrosine tert-butyl ether; (2S)-3-[4-(tert-Butoxy)phenyl]-2-[(9H-fluoren-9-ylmethoxy)formamido]propanoic acid; Fmoc-Hht(OtBu)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homotyrosine(Otbu) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.