Description

8-Fluoro-1,2,3,4-Tetrahydroquinoline-2-Carboxylic Acid is a high-value fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a fused tetrahydroquinoline ring system with a carboxylic acid handle and a fluorine substituent, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries seeking to incorporate fluorinated motifs to modulate the biological activity, metabolic stability, and physicochemical properties of new chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research where fluorinated quinolines are prevalent.
• Agrochemical Synthesis: Serves as a precursor in the design and synthesis of new-generation herbicides, fungicides, and insecticides, leveraging fluorine's ability to enhance bioavailability and target binding.
• Ligand and Catalyst Development: The carboxylic acid and nitrogen functionalities allow its use in constructing chiral ligands for asymmetric catalysis or as a component in metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced organic materials, such as fluorinated liquid crystals or polymers with specific electronic or optical properties.
• Chemical Biology Probes: Used to create fluorinated analogs of natural products or biological molecules for mechanistic studies and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	8-Fluoro-1,2,3,4-Tetrahydroquinoline-2-Carboxylic Acid
CAS No.	219949-91-4
Molecular Formula	C10H10FNO2
Molecular Weight	195.19 g/mol
Synonyms	8-Fluoro-1,2,3,4-tetrahydroquinoline-2-carboxylic acid; 2-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-8-fluoro-; 8-Fluoro-1,2,3,4-tetrahydro-2-quinolinecarboxylic acid; 8-Fluoro-2-carboxytetrahydroquinoline; 219949-91-4; 8-Fluoro-THQ-2-COOH; F-Tetrahydroquinoline-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 8-Fluoro-1,2,3,4-Tetrahydroquinoline-2-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, consistency, and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.