Description

Pentanenitrile, 2,2-Difluoro-4,4-Dimethyl-3-Oxo- is a high-purity, specialty fluorinated nitrile building block. This compound is valued for its unique molecular structure, which incorporates both a reactive nitrile group and a difluorinated ketone moiety, making it a versatile intermediate for advanced synthesis. It is primarily sought by R&D and production chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of fluorinated heterocycles and active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the introduction of fluorine atoms can improve efficacy and environmental profile.
• Organic Synthesis Building Block: Serves as a versatile precursor for nucleophilic substitution and cyclization reactions to create complex, fluorinated organic frameworks in fine chemical manufacturing.
• Material Science Research: Investigated as a monomer or additive for developing specialty polymers with tailored properties, such as chemical resistance or specific optical characteristics.
• Ligand and Catalyst Development: Employed in the synthesis of novel fluorinated ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	Pentanenitrile, 2,2-Difluoro-4,4-Dimethyl-3-Oxo-
CAS No.	219866-68-9
Molecular Formula	C7H9F2NO
Molecular Weight	161.15 g/mol
Synonyms	2,2-Difluoro-4,4-dimethyl-3-oxopentanenitrile; 4,4-Dimethyl-2,2-difluoro-3-oxopentanenitrile; 3-Oxo-2,2-difluoro-4,4-dimethylpentanenitrile; Difluorodimethyloxopentanenitrile; α,α-Difluoro-β-ketopivalonitrile
EINECS	Contact for details

Quality Control

Our Pentanenitrile, 2,2-Difluoro-4,4-Dimethyl-3-Oxo- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is sensitive to strong alkalis and fluorides; keep away from incompatible substances. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Density (20°C)	~1.15 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.