Description

4-Piperidineacetic Acid, .Alpha.-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Methyl Ester is a high-purity, protected amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a critical building block (synthon) for the development of novel pharmaceutical candidates and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry and process development for complex target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing piperidine or modified amino acid motifs.
• Peptidomimetic Research: Used to construct non-natural amino acid residues for the development of peptide analogs with enhanced stability and biological activity.
• Medicinal Chemistry Scaffold: Employed as a core structure for generating compound libraries in drug discovery programs targeting neurological and metabolic disorders.
• Chemical Biology Probes: Acts as a versatile handle for creating labeled or tagged molecules used to study biological pathways and protein interactions.
• Process Chemistry: Serves as a standardized, high-quality starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	4-Piperidineacetic Acid, .Alpha.-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Methyl Ester
CAS No.	219832-76-5
Molecular Formula	C13H24N2O4
Molecular Weight	272.34 g/mol
Synonyms	Methyl N-(tert-butoxycarbonyl)-4-piperidylglycinate; Boc-4-Piperidylglycine Methyl Ester; N-Boc-4-piperidylglycine methyl ester; (4-Piperidyl)glycine, N-Boc-, methyl ester; N-(tert-Butoxycarbonyl)-4-piperidylglycine methyl ester; α-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-piperidineacetic acid methyl ester; Boc-Pip(4)-Gly-OMe; N-Boc-4-piperidineglycine methyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized by multiple analytical techniques, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects with material produced under quality management systems aligned with ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.