Description

Lisinopril R,S,S-Diketopiperazine CAS NO 219677-82-4 is a key diketopiperazine derivative and a critical intermediate in the synthesis of the widely prescribed antihypertensive drug, Lisinopril. This compound matters for its role in ensuring the structural integrity and pharmacological efficacy of the final active pharmaceutical ingredient (API). Pharmaceutical manufacturers and advanced research organizations require this high-purity intermediate for the development and scalable production of cardiovascular medications.

Application

• Primary Intermediate for the synthesis of the ACE inhibitor Lisinopril.
• Pharmaceutical Research & Development (R&D) for studying structure-activity relationships and metabolic pathways.
• Process Chemistry for optimizing manufacturing routes and scaling up API production.
• Reference Standard for quality control and analytical method development in pharmaceutical labs.
• Chemical Synthesis of novel diketopiperazine-based compounds for biological screening.

Basic Information

Product Name	Lisinopril R,S,S-Diketopiperazine
CAS No.	219677-82-4
Molecular Formula	C11H18N2O3
Molecular Weight	226.27 g/mol
Synonyms	(2S)-1-[(2S)-6-Amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid diketopiperazine; Lisinopril DKP; Lisinopril Impurity; (S,S,S)-Lisinopril Diketopiperazine; 1-[(2S)-6-Amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]-L-proline cyclic derivative; Cyclo(Lys-Pro) derivative; ACE Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our Lisinopril R,S,S-Diketopiperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.