Description

(S)-Naproxen iso-Acyl-β-D-Glucuronide CAS NO 219476-92-3 is a specific glucuronide metabolite of the non-steroidal anti-inflammatory drug (NSAID) naproxen. This compound is of critical importance in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and the safety profile of naproxen. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced analytical chemistry, bioanalytical method development, and metabolite identification studies.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified reference material (CRM) for the quantitative and qualitative analysis of naproxen metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance rates, and bioavailability of naproxen in preclinical and clinical research.
• Bioanalytical Method Development: Essential for developing and validating sensitive LC-MS/MS or HPLC-UV methods to detect and quantify this specific glucuronide conjugate in plasma, serum, or urine.
• Toxicology and Safety Assessment: Employed to assess the potential toxicity and safety profile of naproxen metabolites.
• Impurity Profiling: Acts as an impurity marker or identification standard in the quality control of naproxen active pharmaceutical ingredient (API) and finished dosage forms.
• Enzymology Research: Used as a substrate to study the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes responsible for its formation.

Basic Information

Product Name	(S)-Naproxen iso-Acyl-β-D-Glucuronide
CAS No.	219476-92-3
Molecular Formula	C23H26O10
Molecular Weight	462.45 g/mol
Synonyms	(S)-Naproxen Acyl Glucuronide; (S)-Naproxen 1-O-β-Acyl Glucuronide; Naproxen Acyl-β-D-Glucuronide; Naproxen Glucuronide Metabolite; 1-O-[(2S)-2-(6-Methoxy-2-naphthyl)propanoyl]-β-D-glucopyranuronic Acid; Iso-Naproxen Glucuronide; Naproxen AG; Naproxen Acylglucuronide
EINECS	Contact for details

Quality Control

Our (S)-Naproxen iso-Acyl-β-D-Glucuronide is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch undergoes rigorous identity confirmation, purity analysis, and stability testing. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), chromatographic data, and spectroscopic identification (NMR, MS) is provided to ensure traceability and reliability for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The compound is moisture-sensitive; desiccate at room temperature before opening. Store away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤5.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.