Description

H-Lys(Abz)-Pro-Pro-Pna is a specialized synthetic peptide substrate designed for biochemical research and diagnostic applications. This compound is critical for studying enzyme kinetics and activity, particularly for proteases like dipeptidyl peptidase IV (DPP-IV). It serves as an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic reagent manufacturing sectors seeking reliable and high-purity enzyme substrates.

Application

• Enzyme Activity Assays: Primary substrate for the fluorometric or colorimetric measurement of Dipeptidyl Peptidase IV (DPP-IV/CD26) enzyme activity in research settings.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and characterize potential DPP-IV inhibitors for therapeutic development, such as for type 2 diabetes.
• Biochemical Research: Employed in kinetic studies to determine enzyme parameters (Km, Vmax) and investigate the mechanism of action of various proteases.
• Diagnostic Reagent Manufacturing: Incorporated into the formulation of clinical diagnostic kits for measuring DPP-IV activity in serum or plasma samples.
• Cell Biology Studies: Utilized to probe DPP-IV function and regulation in various cell lines and tissues under different physiological or pathological conditions.
• Quality Control (QC) Testing: Serves as a reference standard or critical reagent in QC laboratories for validating the performance of enzymatic assays and diagnostic systems.

Basic Information

Product Name	H-Lys(Abz)-Pro-Pro-Pna
CAS No.	219138-18-8
Molecular Formula	C₃₄H₄₄N₈O₈
Molecular Weight	668.77 g/mol
Synonyms	H-Lys(Abz)-Pro-Pro-pNA; Lys(Abz)-Pro-Pro-p-Nitroanilide; DPP-IV Substrate (Lys(Abz)-Pro-Pro-pNA); Dipeptidyl Peptidase IV Fluorogenic Substrate; N-[(2S)-6-Amino-1-[[(2S)-1-[[(2S)-1-(4-Nitroanilino)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]-1H-benzimidazole-5-carboxamide; Abz-Gly-Pro-Phe(p-NO₂)-Pro; (Abz)-Lys-Pro-Pro-pNA; Gly-Pro-p-nitroanilide derivative
EINECS	Contact for details

Quality Control

Our H-Lys(Abz)-Pro-Pro-Pna is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation, to ensure it meets the high standards required for sensitive research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.