Description

H-Lys(Boc)-Allyl Ester Hcl is a protected amino acid derivative, specifically an Nε-Boc-protected lysine allyl ester hydrochloride salt, widely used as a critical building block in peptide synthesis. This compound matters for its role in facilitating the controlled elongation of peptide chains, where the Boc group provides orthogonal protection for the lysine side chain, and the allyl ester offers a versatile protecting group for the C-terminus that can be removed under mild, selective conditions. Pharmaceutical researchers and fine chemical manufacturers need it for the development of therapeutic peptides, peptidomimetics, and other bioactive molecules, ensuring high-purity intermediates for complex synthetic routes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Employed as a key monomer for the controlled incorporation of lysine residues, leveraging the orthogonal protection strategy of the Boc and allyl ester groups.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptide fragments where selective deprotection sequences are required.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation Chemistry: The allyl ester moiety can be utilized in further functionalization or conjugation reactions to attach peptides to other molecules or surfaces.
• Research & Development: Essential in academic and industrial R&D labs for exploring new peptide structures and their biological activities.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	H-Lys(Boc)-Allyl Ester Hcl
CAS No.	218938-64-8
Molecular Formula	C15H28N2O4 • HCl
Molecular Weight	352.86 g/mol (Free base: 316.40)
Synonyms	Nε-Boc-L-lysine allyl ester hydrochloride; Allyl N6-[(tert-butoxy)carbonyl]-L-lysinate hydrochloride; Boc-Lys(Allyl)-OH • HCl; (S)-2-Amino-6-((tert-butoxycarbonyl)amino)hexanoic acid allyl ester hydrochloride; H-Lys(Boc)-OAllyl • HCl; Boc-L-Lysine allyl ester hydrochloride; Nα-Boc-Nε-allyloxycarbonyl-L-lysine (common misnomer, verify structure); L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-, allyl ester, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our H-Lys(Boc)-Allyl Ester Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for peptide synthesis and pharmaceutical applications. Certificates of Analysis (COA) providing detailed results for purity, identity, and specific impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.