Description

Boc-(R)-3-Amino-4-(4-Chloro-Phenyl)-Butyric Acid is a high-purity, chiral amino acid derivative protected with a tert-butoxycarbonyl (Boc) group, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled synthesis of complex peptides and peptidomimetics, where the Boc group provides orthogonal protection and the chiral center ensures stereochemical integrity. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, enzyme inhibitors, and other bioactive peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of a specific, protected amino acid residue.
• Chemical Biology Research: Employed in the design and construction of peptide probes, ligands, and tools for studying biological mechanisms and protein-protein interactions.
• API Development: Serves as a critical starting material or intermediate in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to construct molecules with high enantiomeric purity.

Basic Information

Product Name	Boc-(R)-3-Amino-4-(4-Chloro-Phenyl)-Butyric Acid
CAS No.	218608-96-9
Molecular Formula	C15H20ClNO4
Molecular Weight	313.78 g/mol
Synonyms	(R)-3-[(tert-Butoxycarbonyl)amino]-4-(4-chlorophenyl)butanoic acid; (R)-3-(Boc-amino)-4-(4-chlorophenyl)butyric acid; Boc-D-4-Cl-Phe-ψ[CH2NH]-Gly-OH (cyclic form descriptor); N-Boc-3-Amino-4-(4-chlorophenyl)butanoic acid; tert-Butyl (R)-(3-carboxy-3-(4-chlorophenyl)propyl)carbamate; (R)-N-Boc-4-Chloro-β-homophenylalanine; 218608-96-9; Boc-(R)-4-Cl-β-homoPhe-OH
EINECS	Contact for details

Quality Control

Our Boc-(R)-3-Amino-4-(4-Chloro-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.