Description

Boc-L-β-Homoisoleucine CAS NO 218608-82-3 is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on its α-amino function. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled construction of complex peptides and peptidomimetics for research and development. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs engaged in drug discovery, particularly for developing novel therapeutic peptides and studying protein structure-function relationships.

Application

• Peptide Drug Discovery & Development: A key protected intermediate for the synthesis of novel peptide-based pharmaceuticals and bioactive peptides.
• Solid-Phase Peptide Synthesis (SPPS): Used as a building block in automated peptide synthesizers to incorporate the β-homoisoleucine residue into peptide chains.
• Structure-Activity Relationship (SAR) Studies: Enables the exploration of peptide backbone modifications by introducing a β-amino acid homolog of isoleucine to alter conformational and biological properties.
• Biochemical Research: Serves as a tool compound for studying enzyme specificity, peptide stability, and membrane permeability.
• Production of Custom Peptides: Essential for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.
• Development of Peptidomimetics: Used to create peptide analogs with enhanced metabolic stability and bioavailability for therapeutic applications.

Basic Information

Product Name	Boc-L-β-Homoisoleucine
CAS No.	218608-82-3
Molecular Formula	C12H23NO4
Molecular Weight	245.32 g/mol
Synonyms	(2S)-3-Methyl-2-{[(2-methylpropan-2-yl)oxycarbonyl]amino}pentanoic Acid; Boc-β-hIle-OH; N-(tert-Butoxycarbonyl)-L-β-homoisoleucine; tert-Butyloxycarbonyl-L-β-homoisoleucine; N-Boc-L-β-homoisoleucine; Boc-L-β-HomoIle; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylpentanoic Acid
EINECS	Contact for details

Quality Control

Our Boc-L-β-Homoisoleucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.