Description

(S)-2-[2-[Bis(2-Tolyl)Phosphino]Phenyl]-4-tert-Butyl-4,5-Dihydro-Oxazole is a high-value, chiral P,N-ligand essential for asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, particularly in hydrogenation and cross-coupling reactions, which are critical for producing single-enantiomer intermediates in the pharmaceutical and fine chemical industries. This compound is specifically designed for chemists and process engineers in R&D and manufacturing who require precise stereochemical control to synthesize complex, optically active molecules.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones to produce chiral pharmaceutical intermediates.
• Cross-Coupling Reactions: Used in palladium-catalyzed asymmetric cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds with high enantiomeric excess.
• Pharmaceutical Intermediate Synthesis: Critical for the production of active pharmaceutical ingredients (APIs) requiring specific chirality, such as certain antidepressants, antivirals, and cardiovascular drugs.
• Fine Chemical and Agrochemical Manufacturing: Enables the synthesis of enantiomerically pure flavors, fragrances, and advanced crop protection agents.
• Academic and Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel synthetic routes in process chemistry.
• Catalyst Library Development: Used as a benchmark or component in high-throughput screening for discovering new asymmetric catalysts.

Basic Information

Product Name	(S)-2-[2-[Bis(2-Tolyl)Phosphino]Phenyl]-4-tert-Butyl-4,5-Dihydro-Oxazole
CAS No.	218460-00-5
Molecular Formula	C33H34NOP
Molecular Weight	491.60 g/mol
Synonyms	(S)-2-[2-(Di-o-tolylphosphino)phenyl]-4-(tert-butyl)-4,5-dihydrooxazole; (S)-2-[2-Bis(2-methylphenyl)phosphinophenyl]-4-(1,1-dimethylethyl)-2-oxazoline; (S)-t-Bu-PHOX; (S)-tert-ButylPHOX; (S)-4-tert-Butyl-2-[2-(di-o-tolylphosphino)phenyl]-4,5-dihydrooxazole; (S)-2-[2-(Ditolylphosphino)phenyl]-4-tert-butyl-4,5-dihydrooxazole; Ligand (S)-t-BuPHOX
EINECS	Contact for details

Quality Control

Our production of (S)-2-[2-[Bis(2-Tolyl)Phosphino]Phenyl]-4-tert-Butyl-4,5-Dihydro-Oxazole adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for catalytic performance. Each lot is fully characterized by NMR (1H, 13C, 31P), HPLC, and specific optical rotation analysis to confirm identity, chemical purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Specific Rotation [α]	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.