Description

tert-Butyl 1-(3,4-Difluorophenyl)-2-Hydroxyethylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its chiral center and protected amine functionality. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and cardiovascular drugs. It is primarily utilized by research institutions, custom synthesis organizations, and large-scale pharmaceutical manufacturers engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel therapeutic agents, especially for CNS disorders.
• Protease Inhibitor Research: Used in the development of inhibitors targeting specific enzymatic pathways.
• Peptidomimetic Synthesis: Serves as a crucial component for constructing peptide-like molecules with enhanced metabolic stability.
• Asymmetric Synthesis: Employed in chiral pool synthesis and resolution processes due to its defined stereochemistry.
• Agrochemical Intermediate: Potential use in the research and development of advanced, fluorinated agrochemicals.
• Custom Chemical Synthesis: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.

Basic Information

Product Name	tert-Butyl 1-(3,4-Difluorophenyl)-2-Hydroxyethylcarbamate
CAS No.	218449-35-5
Molecular Formula	C13H17F2NO3
Molecular Weight	273.28 g/mol
Synonyms	1-(3,4-Difluorophenyl)-2-[(tert-butoxycarbonyl)amino]ethanol; N-Boc-1-(3,4-difluorophenyl)-2-aminoethanol; tert-Butyl N-[1-(3,4-difluorophenyl)-2-hydroxyethyl]carbamate; (R/S)-tert-Butyl 1-(3,4-difluorophenyl)-2-hydroxyethylcarbamate; BOC-3,4-Difluorophenylethanolamine; Carbamic acid, N-[1-(3,4-difluorophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-(3,4-Difluorophenyl)-2-Hydroxyethylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (Specify enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.