Description

Tris(4-Methylphenyl)Phosphine CAS NO 218281-19-7 is a specialized organophosphorus compound featuring a tertiary phosphine core substituted with three tolyl groups. This structure makes it a valuable ligand in transition metal catalysis, particularly for cross-coupling reactions essential in pharmaceutical and advanced material synthesis. It is primarily sought by R&D chemists and process development teams in the fine chemical, agrochemical, and OLED material industries.

Application

• Catalytic Ligand: A key component in palladium-catalyzed cross-coupling reactions such as Suzuki, Heck, and Negishi couplings for C-C bond formation.
• Pharmaceutical Intermediates: Used in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Material Science: Employed in the production of organic light-emitting diodes (OLEDs) and other electronic materials.
• Agrochemical Synthesis: Facilitates the creation of novel pesticides and herbicides through efficient catalytic processes.
• Polymer Chemistry: Acts as a catalyst or ligand in the polymerization and modification of specialty polymers.
• Academic & Industrial Research: Serves as a versatile reagent for developing new catalytic systems and synthetic methodologies.

Basic Information

Product Name	Tris(4-Methylphenyl)Phosphine
CAS No.	218281-19-7
Molecular Formula	C21H21P
Molecular Weight	304.37 g/mol
Synonyms	Tris(p-tolyl)phosphine; Tri-p-tolylphosphine; P(p-Tol)3; Tris(4-tolyl)phosphine; Tris(4-methylphenyl)phosphane; Phosphorous tris(4-methylphenyl) ester; Tri(4-methylphenyl)phosphate (common misnomer); Ligand P(4-MeC6H4)3
EINECS	Contact for details

Quality Control

Our Tris(4-Methylphenyl)Phosphine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive catalytic applications. Each lot is analyzed with techniques including HPLC, NMR, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This product is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.