Description

1-Boc-4-Fmoc-2-Piperazinecarboxylic Acid is a high-purity, dual-protected piperazine derivative essential for advanced organic synthesis. This compound serves as a critical building block for the controlled, sequential construction of complex molecular architectures, particularly in peptide and medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and sophisticated chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled introduction of piperazine moieties into peptide backbones, enabling the synthesis of conformationally constrained or modified peptides.
• Pharmaceutical Intermediate: Serves as a versatile scaffold in the research and development of drug candidates, including kinase inhibitors, GPCR modulators, and protease inhibitors.
• Combinatorial Chemistry: Used in the generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Protecting Group Strategy: The orthogonal Boc and Fmoc protecting groups allow for selective deprotection, facilitating complex multi-step synthetic routes.
• Chemical Biology Probe Development: Employed in the synthesis of labeled or tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	1-Boc-4-Fmoc-2-Piperazinecarboxylic Acid
CAS No.	218278-58-1
Molecular Formula	C25H28N2O5
Molecular Weight	436.50 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-(9-fluorenylmethoxycarbonyl)-2-piperazinecarboxylic Acid; 1-Boc-4-Fmoc-piperazine-2-carboxylic Acid; 2-Piperazinecarboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-4-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Boc-Fmoc-Pip-OH; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-(9H-fluoren-9-ylmethoxycarbonyl)piperazine-2-carboxylic acid; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-(9H-fluoren-9-ylmethoxycarbonyl)piperazine-2-carboxylic acid; 1-N-Boc-4-N-Fmoc-piperazine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Fmoc-2-Piperazinecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.