Description

1H-Thieno[3,4-D]Imidazole-4-Pentanamide, Hexahydro-n-[2-[(Iodoacetyl)Amino]Ethyl]-2-Oxo-, (3As,4S,6Ar)- is a high-purity, specialized heterocyclic compound featuring a reactive iodoacetyl group. This compound matters as a critical bifunctional linker or intermediate for bioconjugation, enabling the site-specific attachment of probes, drugs, or other molecules to proteins, peptides, or other biomolecules. It is primarily needed by researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic reagent production, where precise chemical modification is essential.

Application

• Bioconjugation Reagent: Used for the site-specific labeling of proteins, antibodies, and peptides via thiol-reactive chemistry.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of targeted therapeutics and antibody-drug conjugates (ADCs).
• Proteomics Research: Employed in cross-linking studies, affinity probe development, and mapping protein-protein interactions.
• Diagnostic Assay Development: Utilized to conjugate enzymes, fluorophores, or other detection molecules to antibodies for ELISA, lateral flow, and other immunoassays.
• Chemical Biology Tool: Acts as a versatile probe for studying enzyme mechanisms or modifying biomolecular surfaces.
• Material Science: Potential use in creating functionalized surfaces or polymers for biosensor applications.

Basic Information

Product Name	1H-Thieno[3,4-D]Imidazole-4-Pentanamide, Hexahydro-n-[2-[(Iodoacetyl)Amino]Ethyl]-2-Oxo-, (3As,4S,6Ar)-
CAS No.	216393-53-2
Molecular Formula	C15H23IN4O3S
Molecular Weight	466.33 g/mol
Synonyms	Hexahydro-N-[2-[(iodoacetyl)amino]ethyl]-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide; (3aS,4S,6aR)-Hexahydro-N-[2-[(iodoacetyl)amino]ethyl]-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide; Biotin-Iodoacetyl Labeling Reagent; Iodoacetyl-LC-Biotin; Iodoacetamide Biotin; Biotinylated Iodoacetamide; Sulfhydryl-reactive Biotin; Thiol-reactive Biotinylation Reagent.
EINECS	Contact for details

Quality Control

Our 1H-Thieno[3,4-D]Imidazole-4-Pentanamide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.