Description

Boc-L-Val-Nitrile is a protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) protected nitrile of L-valine. This compound serves as a crucial chiral building block and intermediate in sophisticated organic synthesis, particularly in the pharmaceutical and biotechnology sectors. Its primary value lies in enabling the controlled synthesis of complex peptides, peptidomimetics, and other bioactive molecules where the stereochemistry of valine is essential. This high-purity intermediate is indispensable for research chemists and process development scientists working on active pharmaceutical ingredients (APIs), novel drug candidates, and fine chemical production.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide-based drugs, protease inhibitors, and other APIs requiring the L-valine moiety.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate valine while the α-amino group is protected by the acid-labile Boc group.
• Prodrug Development: Serves as a precursor for designing prodrugs where the nitrile group can be further modified or serves as a metabolically labile linker.
• Bioconjugation: Employed in the preparation of modified peptides and proteins for research, diagnostics, and therapeutic applications.
• Chemical Biology Probes: Useful in the synthesis of labeled peptides and activity-based probes for studying enzyme function and biological pathways.
• Asymmetric Synthesis: Acts as a starting material or intermediate in the asymmetric synthesis of non-proteinogenic amino acids and other chiral compounds.

Basic Information

Product Name	Boc-L-Val-Nitrile
CAS No.	216319-90-3
Molecular Formula	C₁₀H₁₈N₂O₂
Molecular Weight	198.26 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-valine nitrile; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanenitrile; Boc-Val-CN; Boc-L-Val-CN; N-Boc-L-valinonitrile; tert-Butyl (S)-(1-cyano-2-methylpropyl)carbamate; L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-, nitrile; (S)-2-(tert-Butoxycarbonylamino)-3-methylbutyronitrile
EINECS	Contact for details

Quality Control

Our Boc-L-Val-Nitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification to confirm the integrity of the L-configuration. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.