Description

Boc-L-2-Cyanophenylalanine is a protected, non-natural amino acid derivative featuring a cyano group on the phenyl ring. This compound is a crucial building block in peptide synthesis and medicinal chemistry, enabling the introduction of unique structural and electronic properties into target molecules. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers for developing novel therapeutic peptides and peptidomimetics.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel peptide-based drugs and bioactive compounds.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified phenylalanine residues with a cyano functional handle.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship studies by introducing a polarizable nitrile group, which can act as a hydrogen bond acceptor or be further derivatized.
• Chemical Biology Probes: Serves as a building block for creating labeled peptides or activity-based probes for studying enzyme function and protein-protein interactions.
• Material Science: Potential precursor for specialized polymers or coatings where aromatic nitrile functionalities are desired.

Basic Information

Product Name	Boc-L-2-Cyanophenylalanine
CAS No.	216312-53-7
Molecular Formula	C₁₅H₁₈N₂O₄
Molecular Weight	290.32 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(2-cyanophenyl)propanoic acid; N-(tert-Butoxycarbonyl)-2-cyano-L-phenylalanine; Boc-2-CN-Phe-OH; Boc-L-(2-Cyano)Phe; Boc-2-Cyanophenylalanine; tert-Butyloxycarbonyl-L-2-cyanophenylalanine; N-Boc-2-cyano-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Boc-L-2-Cyanophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.