Description

Fmoc-2-Amino-3-Methoxypropionic Acid is a protected, non-proteinogenic amino acid derivative essential for advanced peptide synthesis. Its core value lies in enabling the precise incorporation of methoxy-modified side chains, which are crucial for studying peptide structure-activity relationships and developing novel bioactive compounds. This high-purity building block is primarily needed by researchers and manufacturers in pharmaceutical R&D, biotechnology, and academic laboratories focused on peptide-based drug discovery and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the automated synthesis of custom peptides with methoxy-functionalized side chains.
• Peptidomimetic Drug Development: Used to introduce structural modifications that enhance metabolic stability, bioavailability, and target specificity of therapeutic peptide candidates.
• Chemical Biology Probes: Enables the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Antibiotic Research: Facilitates the design and synthesis of novel antimicrobial peptides (AMPs) with optimized properties.
• Material Science: Serves as a monomer for creating specialized peptide-based polymers and biomaterials with tailored functionalities.
• Process Development & Scale-Up: Supplied in consistent quality for pilot-scale and commercial manufacturing of peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-2-Amino-3-Methoxypropionic Acid
CAS No.	215189-51-8
Molecular Formula	C19H19NO5
Molecular Weight	341.36 g/mol
Synonyms	Fmoc-2-Amino-3-methoxypropanoic Acid; N-(9-Fluorenylmethoxycarbonyl)-2-amino-3-methoxypropionic Acid; (2R/S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-methoxypropanoic Acid; Fmoc-Amp(OMe)-OH; Fmoc-3-Methoxy-L/D-alanine; Fmoc-DL-2-Amino-3-methoxypropionic Acid; N-Fmoc-2-amino-3-methoxypropanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-2-Amino-3-Methoxypropionic Acid is manufactured under strict quality systems to ensure it meets the exacting standards required for peptide synthesis. Each batch is subjected to rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. Comprehensive Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided to guarantee batch-to-batch consistency and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.