Description

N-(9-Fluorenylmethoxycarbonyl)-D-Proline is a high-purity, chiral amino acid derivative specifically engineered for advanced peptide synthesis. This compound matters as a critical building block in the production of complex, biologically active peptides and peptidomimetics, where stereochemical integrity is paramount. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in solid-phase peptide synthesis (SPPS), particularly for developing therapeutic agents, diagnostic tools, and novel biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the sequential assembly of peptide chains.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Used in academic and industrial R&D for studying protein-protein interactions, enzyme substrates, and receptor ligands.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Proteomics and Bioconjugation: Facilitates the site-specific modification and labeling of peptides for analytical and diagnostic applications.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in the synthesis of non-peptide compounds requiring high enantiomeric purity.

Basic Information

Product Name	N-(9-Fluorenylmethoxycarbonyl)-D-Proline
CAS No.	215178-45-3
Molecular Formula	C₂₀H₁₉NO₄
Molecular Weight	337.37 g/mol
Synonyms	Fmoc-D-Proline; (R)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline; D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-D-Pro-OH; N-Fmoc-D-proline; (2R)-1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester
EINECS	Contact for details

Quality Control

Our N-(9-Fluorenylmethoxycarbonyl)-D-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure compliance with exacting research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.