Description

(S)-1-Fmoc-3-Pyrrolidinol is a high-purity chiral building block and protected amino alcohol derivative, essential for the synthesis of complex pharmaceutical intermediates and bioactive molecules. Its core value lies in providing a stereochemically defined scaffold for constructing peptidomimetics and other active pharmaceutical ingredients (APIs). This compound is critically needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Peptidomimetic Chemistry: Serves as a constrained proline analog or a building block for introducing the 3-hydroxypyrrolidine moiety into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• Protecting Group Strategy: The Fmoc group allows for orthogonal deprotection in multi-step solid-phase and solution-phase peptide synthesis (SPPS).
• Chemical Biology Probes: Building block for creating labeled compounds or activity-based probes used in target identification and validation.
• Material Science: Potential monomer for synthesizing specialty polymers with unique chiral or functional properties.

Basic Information

Product Name	(S)-1-Fmoc-3-Pyrrolidinol
CAS No.	215178-38-4
Molecular Formula	C19H19NO3
Molecular Weight	309.36 g/mol
Synonyms	(S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-pyrrolidinol; (S)-3-Hydroxy-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine; (S)-N-Fmoc-3-hydroxypyrrolidine; (S)-1-(9-Fluorenylmethoxycarbonyl)-3-pyrrolidinol; Fmoc-3-hydroxy-(S)-pyrrolidine; 1-Fmoc-3-pyrrolidinol (S-enantiomer); (S)-1-Fmoc-3-pyrrolidinol; (S)-3-Pyrrolidinol, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our (S)-1-Fmoc-3-Pyrrolidinol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.