Description

Methyl 2-(4’-Acetyl-2-Fluoro-Biphenyl-4-Yl)-Propionate is a high-purity, advanced pharmaceutical intermediate characterized by its specific biphenyl and ester functional groups. This compound is of significant value in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting inflammatory and central nervous system pathways. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development and scale-up of novel therapeutic agents.

Application

• Key Intermediate in API Synthesis: Serves as a critical building block in the multi-step synthesis of proprietary drug candidates, especially non-steroidal anti-inflammatory drugs (NSAIDs) and other small molecule therapeutics.
• Pharmacological Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of analog libraries to optimize drug efficacy and safety profiles.
• Process Chemistry Development: Employed in route scouting and optimization for cost-effective and scalable manufacturing processes of target molecules.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation during API production and regulatory filings.

Basic Information

Product Name	Methyl 2-(4’-Acetyl-2-Fluoro-Biphenyl-4-Yl)-Propionate
CAS No.	215175-83-0
Molecular Formula	C19H17FO3
Molecular Weight	312.34 g/mol
Synonyms	2-(4'-Acetyl-2-fluoro[1,1'-biphenyl]-4-yl)propanoic acid methyl ester; Methyl 2-(4'-acetyl-2-fluorobiphenyl-4-yl)propanoate; 2-Fluoro-4'-(2-methoxycarbonylpropyl)acetophenone; [1,1'-Biphenyl]-4-propanoic acid, 4'-acetyl-2-fluoro-, methyl ester; Methyl α-methyl-4'-(2-fluoro-4-acetylphenyl)benzenepropanoate; 215175-83-0; 2-(4'-Acetyl-2-fluoro-biphenyl-4-yl)-propionic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-(4’-Acetyl-2-Fluoro-Biphenyl-4-Yl)-Propionate is manufactured under cGMP-compliant conditions to ensure batch-to-batch consistency and reliability for critical pharmaceutical applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Comprehensive Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.