Description

Flurbiprofen-D5 is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) flurbiprofen, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical material for pharmaceutical research, drug metabolism and pharmacokinetics (DMPK) studies, and clinical laboratories requiring precise bioanalytical quantification.

Application

• Internal Standard for LC-MS/MS: Primary use as a high-purity internal standard for the accurate quantification of flurbiprofen in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Supports drug metabolism studies (DMPK), pharmacokinetic profiling, and bioavailability/bioequivalence testing during drug development.
• Clinical Research & Toxicology: Enables precise monitoring of flurbiprofen levels in patient samples for therapeutic drug monitoring or forensic analysis.
• Metabolite Identification: Aids in the identification and quantification of flurbiprofen metabolites using advanced mass spectrometry techniques.
• Method Development & Validation: Critical for developing, validating, and ensuring regulatory compliance (FDA, EMA) of robust bioanalytical methods.
• Quality Control in Manufacturing: Used in QC laboratories for the analysis of flurbiprofen in active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	Flurbiprofen-D5
CAS No.	215175-76-1
Molecular Formula	C15H8D5FO2
Molecular Weight	247.28 g/mol
Synonyms	2-Fluoro-α-methyl-[1,1'-biphenyl]-4-acetic-2,3,4,5,6-d5 acid; (RS)-2-(2-Fluorobiphenyl-4-yl)propionic-2,3,4,5,6-d5 acid; Flurbiprofen (phenyl-d5); Deuterated Flurbiprofen; Flurbiprofen-d5 Internal Standard; [1,1'-Biphenyl]-4-acetic-2,3,4,5,6-d5 acid, 2-fluoro-α-methyl-; (±)-Flurbiprofen-d5
EINECS	Contact for details

Quality Control

Our Flurbiprofen-D5 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (≥98% D), chemical purity (by HPLC), and confirmation of structure. We adhere to GMP principles for laboratory chemicals to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D)	≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.