Description

Fmoc-Homoarg(Pmc)-Oh CAS NO 214852-52-5 is a protected amino acid derivative, specifically an Fmoc- and Pmc-protected homoarginine building block, essential for solid-phase peptide synthesis (SPPS). This high-purity reagent is critical for researchers and manufacturers requiring precise control over peptide sequence and structure, enabling the synthesis of complex peptides with enhanced stability and bioactivity. It is primarily used by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled incorporation of homoarginine residues into peptide chains.
• Pharmaceutical Research: For the development of novel peptide-based therapeutics targeting various diseases, where homoarginine can influence bioavailability and receptor binding.
• Bioconjugation & Probe Development: Used in the creation of labeled peptides for diagnostic assays, imaging, and biochemical studies.
• Enzyme Substrate & Inhibitor Design: Serves as a component in designing specific substrates or inhibitors for proteases and other enzymes.
• Material Science: Incorporation into bio-inspired polymers and surfaces to modify physicochemical properties.
• Academic & Contract Research: A fundamental reagent for investigating protein-protein interactions, signal transduction pathways, and peptide structure-activity relationships (SAR).

Basic Information

Item	Detail
Product Name	Fmoc-Homoarg(Pmc)-Oh
CAS No.	214852-52-5
Molecular Formula	C33H47N5O7S
Molecular Weight	657.83 g/mol
Synonyms	Fmoc-Homoarginine(Pmc)-OH; N-α-Fmoc-N-ω-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-homoarginine; Fmoc-Homoarg(Pbf)-OH (common alternate naming); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-ω-[(2,2,5,7,8-pentamethyl-3,4-dihydro-2H-1-benzopyran-6-yl)sulfonyl]-homoarginine; Fmoc-Har(Pmc)-OH; Fmoc-N-ω-(Pmc)-homoarginine; (2S)-5-[[(2,2,5,7,8-Pentamethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Homoarg(Pmc)-Oh is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC and NMR, to verify identity and purity. Certificates of Analysis (COA) detailing specific test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.