Description

Boc-3,5-Diiodo-D-Tyrosine is a protected, iodinated derivative of the non-natural D-enantiomer of the amino acid tyrosine. This compound is a critical synthetic intermediate in peptide chemistry and pharmaceutical research, valued for its role in introducing iodine atoms and chiral centers into complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, radiopharmaceuticals, and biochemical probes.

Application

• Peptide Synthesis Intermediate: A key building block for the solid-phase and solution-phase synthesis of iodinated peptides and peptidomimetics.
• Pharmaceutical Research: Used in the development of thyroid hormone analogs, receptor ligands, and other bioactive molecules where iodine substitution is required for activity or labeling.
• Radiopharmaceutical Precursor: Serves as a precursor for compounds where iodine-125 or iodine-131 isotopes are incorporated for diagnostic imaging or targeted radiotherapy.
• Biochemical Probe Development: Employed to create tagged peptides for studying protein-protein interactions, enzyme activity, and cellular localization.
• Chiral Auxiliary & Resolution Agent: Utilized in asymmetric synthesis due to its D-configuration and bulky, protected side chain.

Basic Information

Product Name	Boc-3,5-Diiodo-D-Tyrosine
CAS No.	214630-08-7
Molecular Formula	C₁₄H₁₇I₂NO₅
Molecular Weight	533.10 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3,5-diiodo-D-tyrosine; Boc-D-Tyr(3,5-I2)-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3-(3,5-diiodo-4-hydroxyphenyl)propanoic acid; tert-Butyl (R)-2-amino-3-(3,5-diiodo-4-hydroxyphenyl)propanoate; 3,5-Diiodo-D-tyrosine, N-Boc derivative; BOC-D-Tyr(3,5-I2); N-Boc-3,5-diiodo-D-tyrosine
EINECS	Contact for details

Quality Control

Our Boc-3,5-Diiodo-D-Tyrosine is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰/D: Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.